of April 5 , 2017 . This information is current as Cyclooxygenase - 2 - Overexpressing Glioma Response by T Regulatory Type 1 + Induction of a CD

نویسندگان

  • John S. Yu
  • Yasuharu Akasaki
  • Gentao Liu
  • Nancy H. C. Chung
  • Moneeb Ehtesham
چکیده

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Induction of a CD4+ T regulatory type 1 response by cyclooxygenase-2-overexpressing glioma.

PGE(2), synthesized by cyclooxygenase-2 (COX-2)-overexpressing tumor, is known to contribute to cellular immune suppression in cancer patients, but the mechanism remains unclear. We report the mechanism of a CD4(+) T regulatory type 1 (Tr1) induction by CD11c(+) mature dendritic cells (DCs) that phagocytose allogeneic and autologous COX-2-overexpressing glioma. A human glioma cell line, U-87MG,...

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تاریخ انتشار 2004